TABLE 1.

Cardiac and non-cardiac clinical clues for possible ATTR-CA.

Non-imaging cardiac red flags for ATTR-CA	Non-cardiac red flags for ATTR-CA
Intolerance of GDMT	Polyneuropathy
Persistent low-level troponin elevation	Autonomic dysfunction/Orthostatic hypotension
Unexplained AV block	Bilateral carpal tunnel syndrome
Family history of cardiomyopathy	Lumbar spine stenosis
HFpEF diagnosis in the absence of risk factors	Diarrhea alternating with constipation

GDMT, guideline directed medical therapy for heart failure; HFpEF, heart failure with preserved ejection fraction.