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Schematic diagram of histone modifications mediating RA progression. Acetylation (HDAC1, SIRT1), methylation (DOTL1, HKDM, JMJD3), or ubiquitination (USP5) of RA-related proteins mediates the expression of RA factors (IL-17, IL-6, AMPK, IL-10, IL-1β, NF-κB, TRAF6, EZH2, RUNX1, SMAD7 IL-4, CCR6, etc.), thereby affecting the proliferation, invasion, and apoptosis of RA-related cells.
