Table 1.
Representative miRNAs associated with RA pathogenesis and progression.
| miRNAs | Expression | Source | Type | Effect | Reference |
|---|---|---|---|---|---|
| miR-124 | upregulation | RA patients | synovial tissues | Inhibit cell proliferation promote apoptosis | (41) |
| miR-126 | upregulation | RA patients | Serum, synovial tissue and synovial fluid | Inhibit apoptosis promote proliferation | (42) |
| miR-128-3p | upregulation | RA patients | PBMC | Regulate the activity of inflammatory factors | (43) |
| miR-138 | upregulation | RA patients | synovial tissues | Regulate the activity of inflammatory factors | (44) |
| miR-145-5p | downregulation | RA patients | synovial tissues | Promote cell proliferation and inflammatory factor expression | (45) |
| miR-155-5p | downregulation | RA patients | plasma | up-regulation of pro-inflammatory cytokines | (46) |
| miR-17 | downregulation | RA patients | synovial tissues | Anti-inflammatory and anti-erosion | (47) |
| miR-410-3p | downregulation | RA patients | synovial tissues | Inhibit cell proliferation promote apoptosis | (48) |
| miR-21 | upregulation | RA patients | synovial tissues | Inhibit cell invasion and inflammatory factor expression | (49) |
| miR-221-3p | upregulation | RA patients | PBMC | Promote inflammatory factor expression | (50) |
| miR-23b | upregulation | RA patients | fibroblast-like synoviocytes | Inhibit inflammatory cytokine expression | (51) |
| miRNA-340-5p | downregulation | RA patients | serums, synovial tissues, FLSs | Inhibit cell proliferation promote apoptosis | (52) |
| miR-431-5p | downregulation | RA patients | synovial tissues, FLSs | Inhibit cell proliferation promote apoptosis | (53) |
| miR-449 | downregulation | RA patients | synovial tissues | Inhibit cell proliferation promote apoptosis | (54) |
| miR-4701-5p | downregulation | RA patients | FLSs | Inhibit cell proliferation promote apoptosis | (55) |
| miR-574-5p | upregulation | RA patients | synovial fluid | promote bone destruction | (56) |
| miR-590-5p | downregulation | RA patients | synovial tissues, FLSs | Inhibit cell proliferation and invasion | (57) |
| miR-6089 | downregulation | RA patients | FLSs, synovial tissues | Inhibit cell proliferation induce apoptosis | (58) |
| miR-613 | downregulation | RA patients | Synovial tissues | Inhibit cell proliferation and invasion promote apoptosis | (59) |
| miR-650 | downregulation | RA patients | Synovial tissues | Inhibit cell proliferation and invasion promote apoptosis | (60) |