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. 2022 Mar 31;49(5):72. doi: 10.3892/ijmm.2022.5128

Figure 7.

Figure 7

FUNDC1 knockdown prevents hypoxia-induced mitophagy. (A) Representative western blotting images. The protein expression of (B) HIF-1α, (C) p62, (D) LC3II, (E) DRP1, (F) TIMM23, (G) TOMM20, (H) Beclin-1 and (I) ATG5 in HDPCs after hypoxic culture and transfection with NC or siRNA was all quantified. The results are presented as the means ± SD from ≥ three independent experiments. *P<0.05, **P<0.01 and ***P<0.001. FUNDC1, FUN14 domain-containing; p-, phosphorylated; Nor, normoxia; Hypo, hypoxia; NC, negative siRNA; si, small interfering; HIF-1α, hypoxia-inducible factor-1α; DRP1, dynamin-related protein 1; TIMM23, translocase of inner mitochondrial membrane 23; TOMM20, translocase of outer mitochondrial membrane 20; ATG5, autophagy related 5.