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. 2022 Mar 24;9:829606. doi: 10.3389/fmed.2022.829606

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Copyright © 2022 Chi, Chen, Xiang, Yao, Wang, Zheng, Xu, Li, Xie, Wang, Liu, Li and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EXOs had beneficial effects on endothelial integrity. (A) Confocal images of human umbilical vein endothelial cells (HUVECs) grown on transwells and treated with lipopolysaccharide (LPS) or LPS plus EXOs. Scale bar = 20 μm. (B) Fluorescein isothiocyanate (FITC)-dextran permeability assay of HUVECs on transwells in the indicated groups (n = 3). ***P < 0.001 vs. the normal control (NC) group; ###P < 0.001 vs. the LPS group. (C) The mRNA expression of inflammatory mediators in HUVECs 24 h after LPS stimulation and EXOs treatment. *P < 0.05, ***P < 0.001 vs. the NC group; ##P < 0.01, ###P < 0.001 vs. the LPS group.