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. 2022 Mar 18;13:816754. doi: 10.3389/fendo.2022.816754

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Copyright © 2022 Chen, Peng, Chueh, Liao, Hsieh, Wu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemical staining of CYP11B2, and CYP11B1, and CYP17A1 in the left adrenal mass with the PRKACA mutation (upper row) and the right classical APA with KCNJ5 mutation (bottom row). Of note, bilateral positive mAPM staining was demonstrated. Left adenoma harboring the PRKACA ^L206R mutation is mostly composed of lipid-poor compact cells with intense expression of CYP11B1 and CYP17A1, and negative expression of CYP11B2. Right adenoma harboring the KCNJ5 ^L168 mutation is mostly composed of lipid-poor compact cells with intense expression of CYP11B2. Scale bar, 500 μm.