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. 2022 Mar 2;50(6):3276–3291. doi: 10.1093/nar/gkac135

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Published by Oxford University Press on behalf of Nucleic Acids Research 2022.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 8. — Molecular role of Cdc48^Ufd1/Npl4 segregase in removal of mislocalized Cse4 from non-centromeric regions. Defects in several pathways contribute to mislocalization of Cse4 to non-centromeric regions and CIN. We propose that Psh1 contributes to polyubiquitination of mislocalized Cse4 and this facilitates the interaction between polyubiquitinated Cse4 and Cdc48^Ufd1/Npl4 segregase complex via Npl4, resulting in the removal of Cse4 from non-centromeric regions for proteasomal degradation.