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. 2022 Mar 7;50(6):3445–3455. doi: 10.1093/nar/gkac158

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Bisulfite mediated deamination of native DNA in the region of RACK7 containing d(TCCC)₅ and d(TCCC)₉. After bisulfite treatment of native DNA at pH 5.3 and 37°C, representative cloned isolates of the region were sequenced and the sequences aligned under the genomic reference sequence from the GRCh38.p12 primary assembly of the human genome (marked Ref. in the figure). d(TCCC)_n elements are depicted in yellow. The alignment shows that deletions of various length have occurred in different cells at the 5′ends of both d(TCCC)₅ and d(TCCC)₉. However, both the level of deamination (blue) and the level of deletion (red) are much more extensive at d(TCCC)₉ than in d(TCCC)₅.