Table 1.

Upstream factors regulating Plin5.

Upstream mediators	Effect target	Upstream regulation effect	First author, year, and reference no.
Molecules
PPAR-α/δ	Muscle	Activation of PPAR-α/δ can increase the expression of Plin5	Bindesbøll C et al., 2012 [44]
C/EBPα	Adipocyte tissue, liver	C/EBPα promotes transcription of the porcine Plin5 gene	Zhou L et al., 2013 [72]
SREBP2	Liver	SREBP2 can inhibition the expression of Plin5	Asimakopoulou A et al., 2014 [70]
LCN2	Liver	Basal expression of Plin5 was significantly reduced in Lcn2−/− cells	Gao X et al., 2017 [93]
Plin4	Heart	Plin4 ablation can reduce Plin5 expression at both mRNA and protein levels	Chen W et al., 2013 [75]
PKA	Heart, liver	Protein kinase A (PKA)-stimulation can enhance Plin5 phosphorylation	Pollak NM et al., 2015 [81]
LDL	Cardiomyocytes	LDL (-) strongly induces Plin5 mRNA expression and protein levels	Bindesbøll C et al., 2012 [44]
Environmental
Hypoxia	Cardiomyocytes	Hypoxia can impair Plin5 upregulation	Revuelta-López E et al., 2015 [27]
Fasting	Liver, heart	Plin5 expression is enhanced	Kimmel AR et al., 2014 [16]
Chronic β3-adrenergic stimulation	Liver	Plin5 expression is enhanced	Kimmel AR et al., 2014 [16]
Endurance exercise	Skeletal muscle	Plin5 expression is enhanced	Kimmel AR et al., 2014 [16]