Table 2.

Downstream factors regulated by Plin5.

Downstream mediators	Effect target	Downstream regulation effect	First author, year, and reference no.
CGI-58/ATGL	Cardiomyocyte, liver, adipocyte tissue, muscle	Plin5 competitively binds to CGI-58 and disrupting the interaction between CGI-58 and ATGL	Wang C et al.. 2015 [35] Pollak NM et al., 2013 [20] Sanders MA et al., 2015 [88] Mason RR et al., 2014 [39]
HSL	Adipocyte tissue	Plin5 interacts with HSL	Macpherson RE et al., 2013 [87]
PPARα/PGC1-α	Muscle	Overexpression of Plin5 promotes expression of genes under control of PPARα and PGC-1α	Bosma M et al., 2013 [50]
	Liver, heart	Plin5 decreases expression of PPARα target genes	Trevino MB et al., 2015 [94] Wang H, et al.,2013 [21]
NF-E2-related factor 2	Heart	Plin5 increases expression of oxidative-induced genes via NF-E2-related factor 2 antioxidative pathway	Wang H et al., 2013 [21]
FGF21	Muscle	Upregulating the Plin5 level drives expression of the FGF21 gene	Harris LA et al., 2015 [41]
cAMP/GPR40	Islet	Ad-Plin5 enhanced glucose-stimulated insulin secretion in GPR40- and cAMP-activated protein kinase- dependent manners	Trevino MB et al., 2015 [90]
PKC/NAPDH	Heart	Plin5-KO suppresses diacylglycerol/ceramide-PKC pathway and NADPH oxidase	Kuramoto K et al., 2014 [28]
NF-κB	Artery	IκBα/NF-κB pathway was activated in Plin5−/−	Zhou PL et al., 2017 [34]
MAPK	Aortic tissue	Plin5-/- activates PI3K/AKT and MAPKs pathways	Zhou PL et al., 2017 [34]
PI3K/AKT	Cardiomyocytes	Plin5-null decreases phosphorylation of PI3K/AKT	Zheng P et al., 2017 [26]