. 2022 Mar 31;2022:3046483. doi: 10.1155/2022/3046483

Table 3.

Acute toxicity in organ and hematological parameters of female mice treated with 2 and 5 g of kg⁻¹ EBSp orally.

Parameters	Control	2 g.kg⁻¹	5 g.kg⁻¹
Body mass (%)	100.5 ± 0.5^a	100.3 ± 0.4^a	102.7 ± 1.0^a
Liver (g.100 g⁻¹ BW)	4.03 ± 0.07^a	5.07 ± 0.25^b	4.96 ± 0.18^b
Kidney (g.100 g⁻¹ BW)	1.12 ± 0.04^a	1.11 ± 0.06^a	1.12 ± 0.03^a
Spleen (g.100 g⁻¹ BW)	0.31 ± 0.02^a	0.32 ± 0.02^a	0.30 ± 0.02^a
Heart (g.100 g⁻¹ BW)	0.50 ± 0.02^a	0.51 ± 0.01^a	0.53 ± 0.01^a
Lung (g.100 g⁻¹ BW)	0.66 ± 0.02^a	0.72 ± 0.02^a	0.74 ± 0.07^a
CNS (g.100 g⁻¹ BW)	1.79 ± 0.05^a	1.92 ± 0.05^a	1.72 ± 0.07^a
Erythrocytes (10⁶.μL⁻¹)	10.26 ± 0.40^a	9.68 ± 0.09^a	9.44 ± 0.11^a
Hemoglobin (g.dL⁻¹)	14.22 ± 0.47^a	13.82 ± 0.15^a	13.40 ± 0.23^a
Hematocrit (%)	56.46 ± 2.51^a	53.86 ± 0.61^a	51.54 ± 0.59^a
MCV (fL)	54.98 ± 0.51^a	55.62 ± 0.42^a	54.60 ± 0.31^a
MCH (pg)	13.86 ± 0.12^a	14.26 ± 0.11^a	14.18 ± 0.13^a
MCHC (%)	25.22 ± 0.30^a	25.68 ± 0.05^a	26.00 ± 0.16^a
RDW-SD (fL)	26.48 ± 0.57^a	26.12 ± 0.16^a	25.84 ± 0.40^a
RDW-CV (%)	19.82 ± 0.40^a	18.72 ± 0.12^a	18.70 ± 0.07^a
Platelet (10³.μL⁻¹)	919.00 ± 244.00^a	706.20 ± 34.86^b	661.00 ± 31.26^b
Leucocytes (10³.μL⁻¹)	2.06 ± 0.25^a	4.83 ± 0.41^b	5.07 ± 0.23^b
Neutrophil (%)	0.09 ± 0.03^a	0.11 ± 0.01^a	0.08 ± 0.02^a
Lymphocyte (%)	1.98 ± 0.24^a	4.71 ± 0.40^b	4.97 ± 0.24^b
Monocyte (%)	0.02 ± 0.01^a	0.01 ± 0.00^a	0.01 ± 0.00^a
Eosinophil (%)	0.00 ± 0.00^a	0.00 ± 0.00^a	0.00 ± 0.00^a
Basophil (%)	0.01 ± 0.00^a	0.00 ± 0.00^a	0.00 ± 0.00^a

BW: body weight; CNS: the central nervous system; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW-SD: red cell distribution width-standard deviation; RDW-CV: red cell distribution width-coefficient of variation. The data are presented as the mean ± standard error of the mean. Different letters indicate significant differences between the groups, with P < 0.05.