Table 3.
Effect of GutGard on haematological parameters of male rats during 90 D oral toxicity study.
| Parameter | Dose (mg/kg) | |||||
|---|---|---|---|---|---|---|
| 0 | 0 (Rev)$ | 250 | 500 | 1000 | 1000 (Rev)$ | |
| Hb (g/dL) | 14.99 ± 0.61 | 16.26 ± 0.62 | 15.53 ± 1.29 | 15.75 ± 0.89 | 14.79 ± 0.70 | 16.64 ± 0.66 |
| RBC × 106 (/μL) | 8.54 ± 0.51 | 9.67 ± 0.34 | 8.59 ± 0.87 | 9.12 ± 0.63 | 7.97 ± 0.37 | 9.51 ± 0.69 |
| HCT (%) | 41.99 ± 2.03 | 47.62 ± 1.61 | 43.42 ± 3.66 | 45.29 ± 3.18∗ | 41.06 ± 1.86 | 47.38 ± 2.98 |
| MCV (fL) | 49.22 ± 1.36 | 49.26 ± 1.76 | 50.68 ± 1.98 | 49.67 ± 1.82 | 51.55 ± 1.50# | 49.86 ± 1.86 |
| MCH (pg) | 17.59 ± 0.55 | 16.82 ± 0.56 | 18.16 ± 0.75 | 17.31 ± 1.24 | 18.57 ± 0.60∗ | 17.56 ± 0.69 |
| MCHC (g/dL) | 35.73 ± 0.44 | 34.10 ± 0.64 | 35.84 ± 0.72 | 34.86 ± 2.00 | 36.01 ± 0.54 | 35.22 ± 1.24 |
| PLTS × 103(/μL) | 319.50 ± 118.44 | 440.20 ± 73.57 | 411.50 ± 61.47 | 416.10 ± 90.78 | 423.20 ± 80.72∗ | 366.40 ± 33.50 |
| WBC × 103 (/μL) | 8.57 ± 3.35 | 9.50 ± 1.78 | 13.65 ± 4.48∗ | 12.08 ± 4.16 | 13.31 ± 5.17∗ | 9.56 ± 2.82 |
| Neutrophils (%) | 21.40 ± 4.27 | 21.20 ± 3.70 | 20.40 ± 4.12 | 21.90 ± 3.70 | 20.30 ± 4.45 | 21.40 ± 4.51 |
| Lymphocytes (%) | 74.90 ± 3.84 | 75.00 ± 3.39 | 76.50 ± 4.14 | 75.20 ± 3.39 | 76.10 ± 4.98 | 75.40 ± 4.04 |
| Eosinophils (%) | 1.30 ± 0.67 | 1.20 ± 0.84 | 0.70 ± 0.82 | 0.80 ± 0.92 | 1.20 ± 0.92 | 1.00 ± 1.00 |
| Monocytes (%) | 2.40 ± 0.52 | 2.60 ± 0.55 | 2.40 ± 0.70 | 2.10 ± 0.57 | 2.40 ± 0.70 | 2.20 ± 0.84 |
| Basophils (%) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| PT (sec) | 14.90 ± 3.21 | 14.80 ± 3.56 | 14.60 ± 3.10 | 14.70 ± 2.75 | 15.10 ± 3.28 | 15.40 ± 3.44 |
Mean ± SD (n = 10); $n = 5. Hb: hemoglobin; RBC: red blood corpuscles; HCT: hematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; WBC: white blood corpuscles; N: neutrophils; L: lymphocytes; E: eosinophils; M: monocytes; B: basophils; PT: prothrombin time; PLTS: platelets; Rev: reversal. ∗ = significant at 95% level of confidence (p ≤ 0.05); # = significant at 99% level of confidence (p ≤ 0.01).