Table 4.
Effect of GutGard on haematological parameters of female rats during 90 D oral toxicity study.
| Parameter | Dose (mg/kg) | |||||
|---|---|---|---|---|---|---|
| 0 | 0 (Rev)$ | 250 | 500 | 1000 | 1000 (Rev)$ | |
| Hb (g/dL) | 16.29 ± 1.56 | 15.64 ± 0.29 | 16.10 ± 2.08 | 15.78 ± 2.08 | 15.34 ± 0.75 | 16.02 ± 1.51 |
| RBC × 106 (/μL) | 8.56 ± 0.45 | 8.47 ± 0.40 | 8.54 ± 0.95 | 8.30 ± 1.05 | 8.12 ± 0.59 | 8.46 ± 0.95 |
| HCT (%) | 44.45 ± 3.92 | 43.70 ± 1.57 | 44.17 ± 5.92 | 42.89 ± 4.99 | 42.01 ± 3.18 | 43.98 ± 4.45 |
| MCV (fL) | 51.89 ± 2.24 | 51.62 ± 0.73 | 51.63 ± 1.50 | 51.71 ± 1.94 | 51.76 ± 1.82 | 52.04 ± 1.17 |
| MCH (pg) | 19.00 ± 1.17 | 18.48 ± 0.58 | 18.84 ± 0.66 | 19.03 ± 0.90 | 18.91 ± 0.81 | 18.98 ± 0.56 |
| MCHC (g/dL) | 36.64 ± 1.12 | 35.80 ± 0.77 | 36.46 ± 0.60 | 36.78 ± 0.77 | 36.58 ± 1.44 | 36.48 ± 0.37 |
| PLTS × 103(/μL) | 336.60 ± 88.50 | 360.20 ± 70.46 | 363.80 ± 93.03 | 392.90 ± 72.10 | 422.80 ± 55.47 | 335.80 ± 79.33 |
| WBC × 103 (/μL) | 9.74 ± 3.85 | 7.32 ± 5.28 | 7.97 ± 2.88 | 9.73 ± 3.93 | 15.73 ± 5.02# | 4.38 ± 0.86 |
| Neutrophils (%) | 22.50 ± 4.30 | 20.80 ± 3.27 | 21.20 ± 4.37 | 20.90 ± 4.15 | 21.40 ± 5.30 | 21.20 ± 4.21 |
| Lymphocytes (%) | 74.20 ± 3.58 | 75.80 ± 2.59 | 75.80 ± 4.21 | 76.10 ± 3.51 | 75.80 ± 5.03 | 75.80 ± 3.90 |
| Eosinophils (%) | 0.90 ± 0.74 | 1.00 ± 0.71 | 0.70 ± 0.67 | 0.90 ± 0.88 | 0.60 ± 0.70 | 0.80 ± 0.84 |
| Monocytes (%) | 2.40 ± 0.70 | 2.40 ± 0.55 | 2.30 ± 0.48 | 2.10 ± 0.57 | 2.20 ± 0.63 | 2.20 ± 0.84 |
| Basophils (%) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| PT (sec) | 15.10 ± 3.07 | 15.40 ± 3.85 | 15.60 ± 3.44 | 15.40 ± 3.06 | 15.60 ± 2.95 | 14.80 ± 4.32 |
Mean ± SD (n = 10); $n = 5. Hb: hemoglobin; RBC: red blood corpuscles; HCT: hematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; WBC: white blood corpuscles; N: neutrophils; L: lymphocytes; E: eosinophils; M: monocytes; B: basophils; PT: prothrombin time; PLTS: platelets; Rev: reversal. ∗ = significant at 95% level of confidence (p ≤ 0.05); # = significant at 99% level of confidence (p ≤ 0.01).