Table 7.
Effect of GutGard on urine parameters of male rats during 90 D oral toxicity study.
| Parameter | Dose (mg/kg) | |||||
|---|---|---|---|---|---|---|
| 0 | 0 (Rev)$ | 250 | 500 | 1000 | 1000 (Rev)$ | |
| Volume (ml) | 4.81 ± 0.76 | 5.10 ± 0.20 | 5.07 ± 0.74 | 5.23 ± 0.47 | 5.00 ± 0.58 | 5.20 ± 0.45 |
| Glucose (mmol/L) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Bilirubin (mmol/L) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Ketones (mmol/L) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Sp.Gr.(g/L) | 1.028 ± 0.003 | 1.027 ± 0.003 | 1.028 ± 0.003 | 1.028 ± 0.003 | 1.028 ± 0.003 | 1.028 ± 0.003 |
| OB (ca CELL/μL) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| pH | 6.20 ± 0.26 | 6.30 ± 0.27 | 6.25 ± 0.26 | 6.25 ± 0.26 | 6.25 ± 0.26 | 6.20 ± 0.27 |
| URB (mmol/L) | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Nitrite | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
Mean ± SD (n = 10); $ n = 5. Rev.: reversal; OB: occult blood; URB: urobilinogen; Sp.Gr.: specific gravity.