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. Author manuscript; available in PMC: 2022 Apr 8.
Published in final edited form as: Acc Chem Res. 2021 Aug 20;54(17):3462–3475. doi: 10.1021/acs.accounts.1c00359

Scheme 4. Proposed Origin of 5-OP-RU (3) During the Synthesis of 15a.

Scheme 4.

aTautomerization22 and in situ dehydration of 1,3-dihydroxyacetone (14) to trace methylglyoxal (11) at 80 °C could produce 5-OP-RU (3) during the synthesis of rRL-6-HM (15).