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Stress effects on astrocytes (yellow) and their interaction with the blood-brain barrier (BBB). As shown in the inset, SLC1A2 (also known as GLT1 or EAAT2) removes glutamate from the extracellular space. SLC1A2 is downregulated in both humans and rodent models of stress and depression. Additionally, loss of astrocyte endfeet integrity may loosen the BBB and allow peripheral factors into the brain.
