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. Author manuscript; available in PMC: 2022 Sep 17.
Published in final edited form as: Nat Immunol. 2022 Mar 17;23(4):632–642. doi: 10.1038/s41590-022-01152-y

Figure 5. Linked IFN-I response and co-inhibitory receptor expression in T cells in COVID-19.

Figure 5

a, UMAP representation of T cells from healthy control samples (n = 13; biologically independent samples) and COVID-19 samples (n = 18; biologically independent samples). 13 subcluster were identified. b, IFN-I score for CD4+ and CD8+ T cells across the three disease conditions. c, Heatmaps for co-inhibitory receptors expression in CD4+ and CD8+ T cells across the three disease conditions. d, Expression of key co-inhibitory receptors between control vs COVID-19 for CD4+ and CD8+ T cells. Average expression per subject for each gene is shown. *p < 0.05, **p < 0.01, ***p < 0.001. Two-sided Kruskal-Wallis test. e, Correlation matrix of ISGs (dark gray) and co-inhibitory receptors (light gray) in CD4+ and CD8+ T cells in COVID-19 patients. f, IFN-I score for subsets of CD4+ and CD8+ T cells between control vs COVID-19.