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. Author manuscript; available in PMC: 2023 Apr 6.
Published in final edited form as: Neuron. 2022 Feb 24;110(7):1100–1115. doi: 10.1016/j.neuron.2022.01.034

Figure 1. Radial progenitors in the developing cerebral cortex.

Figure 1.

(A, B) Major radial glial types and other progenitors in the embryonic neocortex of mice (A) and humans (B). Boxed area (A) illustrates extensive inter-radial glial interactions all along basal processes. (C) MADM (Mosaic Analysis with Double Markers)-based labeling of a single radial unit containing a mother RGC and its progenies in E16 mouse cortex (modified from Nakagawa et al, 2019). Please note that in contrast to the cylindrically shaped radial units in mice, human radial units are more conically shaped due to the existence of oSVZ and abundance of oRGCs (Borrell, 2019). (D) Laminar and area-specific allocation of distinct types and numbers of neurons in human cortex resulting from embryonic radial glial development, organization, and function (modified from Shapson-Coe et al, 2021). Radial glial interactions with axons, interneurons, vasculature, and glia (astrocytes, microglia, and ependymal cells) are not illustrated. I-VI; cortical layers; WM, white matter.