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. Author manuscript; available in PMC: 2022 Sep 14.
Published in final edited form as: Nat Immunol. 2022 Mar 14;23(4):543–555. doi: 10.1038/s41590-022-01163-9

Figure 1. BNT162b2 vaccine induces robust germinal center B cell and TFH response in mice.

Figure 1.

a, Experimental timeline and tests. b, Serum anti-S IgG, IgG1a, and IgG2c binding titers detected by ELISA. c, Pseudo-typed lentivirus neutralization antibody titers against SARS-CoV-2 WT and variants of concern (B.1.429, B.1.1.7, B.1.351, P.1 and B.1.617.2) measured at days 21 and 42. n=10 mice per time point in b-c. d-f, Germinal center B cell (d), T follicular helper cell (e), and plasma cell (f) response after BNT162b2 immunization. n=11, 13, 16, 10 for day 0, 7, 14, 21, respectively. Data were combined from two or more independent experiments. One-Way ANOVA followed by Tukey’s test was applied in (b-f). *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001. Differences between groups were considered significant for P-values < 0.05.