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. Author manuscript; available in PMC: 2022 Sep 14.
Published in final edited form as: Nat Immunol. 2022 Mar 14;23(4):543–555. doi: 10.1038/s41590-022-01163-9

Figure 3. BNT162b2 induces robust innate immune response in draining lymph nodes.

Figure 3.

a, Activation of innate cells at day 1 after BNT162b2 immunization in dLNs indicated by activation marker CD86. b, Dynamics of innate cell activation at days 1, 3, and 7 after BNT162b2 immunization. n=20, 16, 7, 5 for day 0, 1, 3, and 7, respectively. c-d, Innate cell activation in contralateral lymph nodes (non-dLN) compared to that in dLNs (c), and in lung and spleen (d) at day 1 post-prime. n=5 for each group. e, Dynamics of cytokines in serum at 0, 6, 24 and 72 h after BNT162b2 immunization. n=10 for 0 and 6h, n=5 for 24h and 72h. Data were combined from at least two independent experiments (a, b, e) or one representative of two independent experiments (c, d). One-Way ANOVA followed by Tukey’s test was applied in (b-e). *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.