TABLE 1.

Number of viable M. tuberculosis organisms recovered in spleens and lungs following 6, 8, 10, or 12 weeks of RLZ-INH treatment^a

Duration (wk)	Mean ± SD log no. of CFU in spleens			Mean ± SD log no. of CFU in lungs
	Controlb	Treatment	Treatment + observationc	Control	Treatment	Treatment + observation
0d	7.21 ± 0.22 (7/7)e			5.99 ± 0.21 (7/7)
6		1.08 (1/7)f	3.15 ± 0.56 (7/8)		0.30 (1/7)	2.68 ± 0.15 (4/8)
8		0 (0/8)	2.93 ± 0.53 (5/8)		0.70 (1/8)	2.54 (1/8)
10		0 (0/8)	0.22 ± 0.00 (2/8)		0 (0/8)	1.45 (1/8)
12	4.48 ± 0.66 (5/5)	0 (0/8)	0 (0/8)	5.99 ± 0.70 (5/5)	0 (0/8)	0 (0/8)

^aGroups treated in parallel were maintained to observe regrowth. The mean log number of CFU was calculated for mice in which growth occurred. 

^bOne mouse in the 12-week control group died, while the data for the other mice could not be used due to technical error. 

^cFour-month observation phase. 

^dWeek 0 represents the beginning of treatment (1 week postinfection). 

^eThe values in parentheses represent the number of mice per group (eight per group) in which viable M. tuberculosis was detected/total number of mice in the group. 

^fOne mouse died.