TABLE 2.

Number of viable M. tuberculosis organisms recovered following 6, 8, or 10 weeks of RLZ-INH or RLZ-INH-PZA treatment^a

Duration (wk)	Mean ± SD log no. of CFU in spleens			Mean ± SD log no. of CFU in lungs
	Control	RLZ-INH	RLZ-INH-PZA	Control	RLZ-INH	RLZ-INH-PZA
0b	7.12 ± 0.27 (8/8)c			6.45 ± 0.44 (8/8)
6	6.01 ± 0.81 (8/8)	0.77 ± 0.40 (3/8)	0.85 (1/8)	7.19 ± 0.29 (8/8)	0 (0/8)	0.30 ± 0.00 (2/8)
8		0 (0/8)	0 (0/8)		0 (0/8)	0 (0/8)
10		0 (0/8)	0 (0/8)		0 (0/8)	0 (0/8)
6 + obsd		2.69 ± 0.87 (8/8)	3.27 ± 0.12 (5/8)		2.60 ± 0.49 (3/8)	3.43 ± 0.00 (2/8)
8 + obs		3.31 ± 0.14 (5/8)	2.08 ± 0.00 (3/8)		0 (0/8)	0 (0/8)
10 + obs		0 (0/8)	0 (0/8)		0 (0/8)	0 (0/8)

^aGroups treated in parallel were maintained to observe regrowth. The mean log number of CFU was calculated for mice in which growth occurred. 

^bWeek 0 represents the beginning of treatment (1 week postinfection). 

^cThe values in parentheses represent the number of mice per group (eight per group) in which viable M. tuberculosis was detected/total number of mice in the group. 

^dThree-month observation (obs) phase.