Fig. 1.

The universal character of nucleocapsid protein. (A)Structure of the virus. (B) Domain architecture of SARS-CoV-2 N protein. (C) Predicted structure of nucleocapsid protein with post-translational modification prepared using the Robetta comparative modelling tools and two templates, the NMR structure of the RNA-binding domain (PDB:1SSK) and the X-ray structure of the dimerization domain (PDB:6YUN) (details in Fig. S8.). The identity of nucleocapsid and spike proteins of different human coronaviruses has been listed in Tables S1 and S2.