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. Author manuscript; available in PMC: 2022 Oct 4.
Published in final edited form as: Pediatr Res. 2021 Oct 8;92(2):415–423. doi: 10.1038/s41390-021-01747-5

Figure 3. Impact of Time of Initiation on the Efficacy of Azithromycin Neuroprotection in LPS+HI.

Figure 3.

Outcomes of AZ*5 regimens with initial dose administration at 1, 2, or 4 h after the end of HI were compared with NS controls (a-d) were assessed at P21; %intact right hemisphere (c) was calculated using bilateral hemisphere weights. AZ*5 treatment initiated at 1 or 2 h post-HI, but not at 4 h, conferred improvements in each measure and Composite Score compared to controls (p<0.0001, Kruskal-Wallis, *p≤0.0001 Dunn’s). A linear decrement in AZ efficacy with increasing delay in treatment initiation was evident (p<0.0001 post-hoc linear test for trend).