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. Author manuscript; available in PMC: 2022 Oct 4.
Published in final edited form as: Pediatr Res. 2021 Oct 8;92(2):415–423. doi: 10.1038/s41390-021-01747-5

Figure 6. Impact of Time of Initiation on the Efficacy of Azithromycin Neuroprotection in PAM+HI.

Figure 6.

Outcomes of AZ*5 regimens with initial dose administration at 1, 2, or 4 h after the end of HI were compared with NS controls; outcomes were assessed at P21 (a-d) as in Fig. 3. AZ*5 treatment initiated at 1 or 2 h post-HI, but not at 4 h, conferred improvements in Composite Score (d) and sensorimotor test measures (a, b) (p<0.005, Kruskal-Wallis; * p<0.05 Dunn’s); %intact right hemisphere was only significantly greater than controls for the 1 h delay group (c; *p<0.05 Dunn’s). Overall, a linear decrement in AZ efficacy with increasing delay in treatment initiation from 1 h to 4 h vs. NS was evident (p<0.0001 post-hoc linear test for trend).