Table 1.
Baseline characteristics of patients with metastatic gastric adenocarcinoma (with and without bone metastasis), 2010–2016a.
| Variable | Category/comment | With bone metastasis | Without bone metastasis |
|---|---|---|---|
| n | 1,511 | 9,561 | |
| Year of diagnosis | 2014–2016 | 728 (48) | 4,277 (45) |
| Sex | Male | 1,002 (66) | 6,136 (64) |
| Age (years) | As continuous | 61 ± 14, 61 (52–70) | 64 ± 14, 64 (54–74) |
| <50 | 314 (21) | 1,477 (15) | |
| 50–59 | 354 (23) | 2,108 (22) | |
| 60–69 | 449 (30) | 2,573 (27) | |
| 70–79 | 267 (18) | 2,022 (21) | |
| ≥80 | 127 (8) | 1,381 (14) | |
| Ethnicity | White | 1,120 (74) | 6,817 (71) |
| Black | 162 (11) | 1,322 (14) | |
| American Indian/Alaska Native | 19 (1) | 109 (1) | |
| Asian/Pacific Islander | 206 (14) | 1,262 (13) | |
| Other unspecified/unknown | 4 (<1) | 51 (1) | |
| Tumor location b | Gastric cardia | 584 (62) | 3,111 (52) |
| Gastric fundus/body | 176 (19) | 1,257 (21) | |
| Gastric antrum/pylorus | 175 (19) | 1,659 (28) | |
| Other | 576 (38) | 3,534 (37) | |
| Signet ring cell carcinoma | Yes | 429 (28) | 2,048 (21) |
| Differentiation c | Well | 13 (1) | 155 (2) |
| Intermediate | 175 (15) | 1,719 (23) | |
| Poor/undifferentiated | 954 (84) | 5,581 (75) | |
| Adjacent structure invasion d | Yes | 159 (23) | 1,446 (26) |
| Positive lymph node e | Yes | 725 (59) | 4,513 (56) |
| Brain metastasis | Yes | 74 (5) | 147 (2) |
| Liver metastasis | Yes | 511 (34) | 4,194 (44) |
| Lung metastasis | Yes | 347 (23) | 1,283 (13) |
| Resection | Yes | 55 (4) | 1,115 (12) |
| Chemotherapy f | Yes | 911 (60) | 5,769 (60) |
| Radiotherapy f | Yes | 454 (30) | 1,394 (15) |
| Follow-up (months) g | As continuous | 33 (18–61) | 36 (16–59) |
| Accumulated follow-up (person-years) | As continuous | 696 | 6303 |
| Median survival (months) | As continuous | 4 (1–8) | 5 (1–13) |
| Cause of death | Alive | 169 (11) | 1,540 (16) |
| Cancers | 1,297 (86) | 7,676 (80) | |
| Non-cancer diseases | 45 (3) | 345 (4) |
Categorical data are shown as count (percentage [%]), and continuous data as mean ± standard deviation, median (interquartile range). Records are complete otherwise specified below.
The proportions of cancers located in gastric cardia, fundus/body, and antrum/pylorus were calculated within these 3 categories. Other means lesser curvature, greater curvature, overlapping lesion of stomach, and stomach (not otherwise specified).
Missing differentiation grade: metastatic with bone metastasis, 369 (24%); metastatic without bone metastasis, 2,106 (22%).
Missing local invasion: metastatic with bone metastasis, 828 (55%); metastatic without bone metastasis, 4,086 (43%).
Missing positive lymph node: metastatic with bone metastasis, 290 (19%); metastatic without bone metastasis, 1,567 (16%).
The other category for the non-surgical variables was “No/unknown,” considering the low sensitivity.
Shown as median (interquartile range), and computed using the reverse Kaplan–Meier method.
NE, not estimable.