TABLE 3.
Multivariable model of factors associated with sensitization including interactions with HLA homozygosity
| Sensitization group | ||||||
|---|---|---|---|---|---|---|
| Mildly sensitized (CPRA 1–69) | Highly sensitized (CPRA 70–94) | Extremely sensitized (CPRA 95–100) | ||||
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| Number of homozygous HLA loci | 1.08 (1.03-1.14) | 0.002 | 0.96 (0.87-1.05) | 0.383 | 1.10 (1.00-1.20) | 0.044 |
| Sex | ||||||
| Male | Reference | Reference | Reference | |||
| Female | 1.61 (1.56-1.67) | <0.001 | 5.55 (5.22-5.90) | <0.001 | 5.36 (5.02-5.72) | <0.001 |
| Sex × HLA homozygosity | ||||||
| Female | 0.98 (0.96-1.01) | 0.149 | 1.07 (1.02-1.11) | 0.004 | 1.15 (1.11-1.21) | <0.001 |
| Age (per decade) | 0.99 (0.98-1.00) | 0.147 | 1.01 (0.99-1.03) | 0.286 | 0.93 (0.91-0.95) | <0.001 |
| Age × HLA homozygosity | 1.00 (0.99-1.01) | 0.897 | 1.02 (1.01-1.04) | 0.002 | 1.03 (1.02-1.05) | <0.001 |
| Ethnicity | ||||||
| White | Reference | Reference | Reference | |||
| Black | 1.38 (1.33-1.44) | <0.001 | 1.75 (1.64-1.87) | <0.001 | 2.96 (2.76-3.19) | <0.001 |
| Hispanic/Latinx | 0.95 (0.91-1.00) | 0.050 | 1.12 (1.03-1.21) | 0.009 | 1.56 (1.42-1.70) | <0.001 |
| Asian | 0.98 (0.91-1.05) | 0.582 | 0.93 (0.82-1.06) | 0.308 | 1.14 (0.99-1.32) | 0.066 |
| Ethnicity × HLA homozygosity | ||||||
| Black | 0.99 (0.96-1.02) | 0.450 | 0.98 (0.94-1.03) | 0.524 | 0.97 (0.92-1.02) | 0.204 |
| Hispanic/Latinx | 0.98 (0.94-1.01) | 0.179 | 1.01 (0.95-1.07) | 0.807 | 0.98 (0.93-1.04) | 0.549 |
| Asian | 1.03 (0.98-1.08) | 0.197 | 1.09 (1.01-1.178) | 0.030 | 1.05 (0.97-1.13) | 0.260 |
| Diabetes | ||||||
| None | Reference | Reference | Reference | |||
| Type 1 | 0.95 (0.87-1.04) | 0.283 | 0.74 (0.64-0.86) | <0.001 | 0.75 (0.64-0.87) | <0.001 |
| Type 2 | 1.01 (0.98-1.05) | 0.450 | 0.97 (0.97-1.04) | 0.400 | 0.92 (0.86-0.99) | 0.031 |
| Unknown type | 0.95 (0.79-1.15) | 0.618 | 0.84 (0.61-1.16) | 0.293 | 0.98 (0.72-1.32) | 0.871 |
| Diabetes × HLA homozygosity | ||||||
| Type 1 | 0.98 (0.92-1.05) | 0.577 | 1.03 (0.93-1.13) | 0.589 | 1.07 (0.98-1.17) | 0.147 |
| Type 2 | 1.00 (0.98-1.03) | 0.885 | 1.01 (0.96-1.05) | 0.768 | 0.98 (0.93-1.02) | 0.328 |
| Unknown type | 0.90 (0.79-1.03) | 0.138 | 0.89 (0.71-1.12) | 0.316 | 0.94 (0.77-1.14) | 0.543 |
| Blood type | ||||||
| O | Reference | Reference | Reference | |||
| A | 0.94 (0.91-0.98) | 0.001 | 0.93 (0.88-1.00) | 0.036 | 0.95 (0.89-1.02) | 0.157 |
| B | 1.04 (0.99-1.09) | 0.145 | 1.02 (0.94-1.11) | 0.652 | 1.12 (1.03-1.23) | 0.010 |
| AB | 0.88 (0.81-0.96) | 0.004 | 0.87 (0.75-1.01) | 0.066 | 0.85 (0.72-1.00) | 0.055 |
| Blood type × HLA homozygosity | ||||||
| A | 1.00 (0.97-1.03) | 0.868 | 1.01 (0.97-1.06) | 0.574 | 1.03 (0.98-1.07) | 0.242 |
| B | 0.99 (0.96-1.03) | 0.625 | 0.99 (0.93-1.05) | 0.685 | 0.96 (0.91-1.02) | 0.173 |
| AB | 0.98 (0.92-1.05) | 0.564 | 1.05 (0.94-1.16) | 0.380 | 1.02 (0.92-1.14) | 0.712 |
| Prior kidney Txp | ||||||
| No | Reference | Reference | Reference | |||
| Yes | 2.30 (2.16-2.45) | <0.001 | 12.64 (11.72-13.63) | <0.001 | 40.88 (37.95-44.03) | <0.001 |
| Prior kidney Txp × HLA homozygosity | ||||||
| Yes | 0.93 (0.89-0.98) | 0.007 | 1.01 (0.96-1.07) | 0.682 | 0.98 (0.93-1.03) | 0.459 |
CPRA, calculated panel reactive antibody; Txp, transplant.