Table 3.
Summary of LDL-C and CIMT data in eight Greek patients
| Patient number | Current age, years | Genotype | Untreated LDL-C, mg/dL | LDL-C before lomitapide, mg/dL | Date Lomitapide commenced | Lowest LDL-C on lomitapide, mg/dL | Baseline CIMT, mm | Last CIMT, mm | Interval between CIMT, years | Change in CIMT, mm | Comments |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 56.0 | c.1285G>A | 900 | 600 | 2015 | 84 | 0.65 | 0.6 | 5 | − 0.05 | CABG; AVR; RC endarterectomy; endocarditis |
| 2 | 31.1 | c.1448G>A, c.1646G>A | 900 | 545 | 2014 | 135 | 1.10 | 1.25 | 6 | 0.15 | – |
| 3 | 24.8 | c.1285G>A | 1100 | 345 | 2015 | 149 | 0.60 | 0.85 | 4 | 0.25 | PCI |
| 4 | 26.6 | c.1285G>A | 1050 | 410 | 2015 | 155 | 0.90 | 0.6 | 3 | − 0.30 | PCI; AVR |
| 5 | 26.8 | c.1285G>A | 950 | 371 | 2014 | 74 | 1.05 | 0.9 | 2 | − 0.15 | AVR; MVR |
| 6 | 41.9 | c.81C>G, c.1646G>A | UNK* | 370 | 2017 | 120 | 1.05 | 1.45 | 2 | 0.40 | PCI |
| 7 | 62.8 | UNK | 750 | 366 | 2016 | 143 | UNK | 1.1 | 3 | – | Endarterectomy; stenosis; CABG, AVR |
| 8 | 19.7 | c.666C>A, c.1646G>A | 1213 | 474 | 2016 | 191 | 0.60 | 0.6 | 4 | 0.00 | AV stenosis |
| Mean | 36.2 | 980 | 435 | 131 | 0.85 | 0.92 | 3.63 | 0.04 | |||
| SD | 14.7 | 153 | 95 | 38 | 0.23 | 0.32 | 1.41 | 0.24 |
*Total cholesterol 770mg/dL.
AV aortic valve, AVR aortic valve replacement, CABG coronary artery bypass graft, CIMT carotid intima-media thickness, F female, LDL-C low-density lipoprotein cholesterol, M male, MVR mitral valve replacement, PCI percutaneous coronary intervention, RC right carotid, UNK unknown