TABLE 2.
Gastric cancer-related targets of D. officinale extract.
| Number | Protein name | Gene name |
|---|---|---|
| 01 | Brain-derived neurotrophic factor | BDNF |
| 02 | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
| 03 | Alpha-enolase | ENO1 |
| 04 | Interleukin-1 beta | IL1B |
| 05 | Interleukin-6 | IL6 |
| 06 | Prostaglandin G/H synthase 2 | PTGS2 |
| 07 | Superoxide dismutase [Mn] | SOD2 |
| 08 | Tumor necrosis factor | TNF |
| 09 | Alpha-fetoprotein | AFP |
| 10 | Aryl hydrocarbon receptor | AHR |
| 11 | Aldo-keto reductase family 1 member C3 | AKR1C3 |
| 12 | Albumin | ALB |
| 13 | Bcl-2-like protein 1 | BCL2L1 |
| 14 | G1/S-specific cyclin-D1 | CCND1 |
| 15 | Interleukin-8 | CXCL8 |
| 16 | Epidermal growth factor receptor | EGFR |
| 17 | Heme oxygenase 1 | HMOX1 |
| 18 | Mitogen-activated protein kinase 1 | MAPK1 |
| 19 | Mitogen-activated protein kinase 3 | MAPK3 |
| 20 | Mitogen-activated protein kinase 8 | MAPK8 |
| 21 | Peroxisome proliferator-activated receptor gamma | PPARG |
| 22 | Protein kinase C beta type | PRKCB |
| 23 | Plasminogen activator inhibitor 1 | SERPINE1 |
| 24 | Zinc finger protein SNAI1 | SNAI1 |
| 25 | Signal transducer and activator of transcription 3 | STAT3 |
| 26 | Cellular tumor antigen p53 | TP53 |
| 27 | Caspase-8 | CASP8 |
| 28 | Polyunsaturated fatty acid 5-lipoxygenase | ALOX5 |
| 29 | V-type proton ATPase subunit d 2 | ATP6V0D2 |
| 30 | Growth arrest and DNA damage-inducible protein GADD45 alpha | GADD45A |
| 31 | Glutathione S-transferase P | GSTP1 |
| 32 | Nitric oxide synthase | NOS3 |
| 33 | 5′-Nucleotidase | NT5E |
| 34 | Peroxiredoxin-5 | PRDX5 |
| 35 | 5-Hydroxytryptamine receptor 1A | HTR1A |
| 36 | Transcription factor AP-1 | JUN |
| 37 | 40S ribosomal protein S6 | RPS6 |
| 38 | Carbonic anhydrase 1 | CA1 |
| 39 | Carbonic anhydrase 2 | CA2 |
| 40 | Cytochrome P450 2A6 | CYP2A6 |
| 41 | DNA (cytosine-5)-methyltransferase 3B | DNMT3B |
| 42 | Fibroblast growth factor receptor 2 | FGFR2 |
| 43 | Metallothionein-2 | MT2A |
| 44 | Angiotensin-converting enzyme | ACE |
| 45 | Type-2 angiotensin II receptor | AGTR2 |
| 46 | DNA-(apurinic or apyrimidinic site) endonuclease | APEX1 |
| 47 | Apolipoprotein A-I | APOA1 |
| 48 | Serine-protein kinase ATM | ATM |
| 49 | BH3-interacting domain death agonist | BID |
| 50 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | BNIP3 |
| 51 | Caveolin-1 | CAV1 |
| 52 | Cadherin-1 | CDH1 |
| 53 | Cyclin-dependent kinase 4 | CDK4 |
| 54 | Serine/threonine-protein kinase Chk2 | CHEK2 |
| 55 | Procathepsin L | CTSL |
| 56 | DNA (cytosine-5)-methyltransferase 1 | DNMT1 |
| 57 | Extracellular matrix protein 1 | ECM1 |
| 58 | Elongation factor 1-alpha 1 | EEF1A1 |
| 59 | Tyrosine-protein kinase Fyn | FYN |
| 60 | Gastrin | GAST |
| 61 | GTPase HRas | HRAS |
| 62 | Heat shock protein beta-1 | HSPB1 |
| 63 | Matrilysin | MMP7 |
| 64 | Adenine DNA glycosylase | MUTYH |
| 65 | Myc proto-oncogene protein | MYC |
| 66 | Prohibitin | PHB |
| 67 | 5′-AMP-activated protein kinase catalytic subunit alpha-1 | PRKAA1 |
| 68 | Major prion protein | PRNP |
| 69 | Regulator of G-protein signaling 2 | RGS2 |
| 70 | 60S ribosomal protein L13 | RPL13 |
| 71 | 40S ribosomal protein S19 | RPS19 |
| 72 | 40S ribosomal protein S26 | RPS26 |
| 73 | Plasminogen activator inhibitor 1 RNA-binding protein | SERBP1 |
| 74 | Alpha-1-antitrypsin | SERPINA1 |
| 75 | Sterol regulatory element-binding protein 2 | SREBF2 |
| 76 | Thymidylate synthase | TYMS |
| 77 | UL16-binding protein 2 | ULBP2 |
| 78 | Caspase-10 | CASP10 |
| 79 | Protein canopy homolog 2 | CNPY2 |
| 80 | Enoyl-CoA hydratase | ECHS1 |
| 81 | 60 kDa heat shock protein | HSPD1 |
| 82 | Interleukin-32 | IL32 |
| 83 | Insulin receptor substrate 2 | IRS2 |
| 84 | Nucleophosmin | NPM1 |
| 85 | Pyruvate dehydrogenase E1 component subunit alpha | PDHA1 |
| 86 | Urokinase-type plasminogen activator | PLAU |
| 87 | Peptidyl-prolyl cis-trans isomerase A | PPIA |
| 88 | Retinoic acid receptor beta | RARB |
| 89 | 60S ribosomal protein L18 | RPL18 |
| 90 | 40S ribosomal protein S15 | RPS15 |
| 91 | Protransforming growth factor alpha | TGFA |
| 92 | UBX domain-containing protein 1 | UBXN1 |
| 93 | Zinc finger protein 593 | ZNF593 |
| 94 | Beta-2 adrenergic receptor | ADRB2 |