Fig. 1.

Study design and protocol. Seventeen pigs were subjected to acute myocardial infarction (AMI), and 5 pigs underwent sham surgery. A perfluorooctyl bromide (PFOB) nanoemulsion was administered on day 3 after AMI. Fifteen pigs underwent in vivo cardiovascular magnetic resonance (CMR + ¹⁹F) with analysis of volumes, contractile function and tissue characterization. In situ and ex vivo magnetic resonance imaging, followed by histology, was performed for validation purposes. EDV end diastolic volume, ESV end systolic volume, SV stroke volume, EF ejection fraction, IS infarct size, IMH intramyocardial hemorrhage, MVO microvascular obstruction