Fig. 6.

The border Zone ¹⁹F signal is associated with impaired remote systolic wall thickening and the whole heart ¹⁹F integral with initial remodeling post-AMI. A Myocardial systolic wall thickening (% of end diastolic thickness, gray) and ¹⁹F signal-to-noise ratio (SNR, orange) of the infarct core (IC), border zone (BZ) and remote myocardium (RM). B Correlation of RM systolic wall thickening to BZ ¹⁹F SNR. (C) ¹⁹F signal distribution across IC, BZ and RM as delineated by ¹H magnetic resonance imaging with late gadolinium enhancement (LGE), D schematic assignment of left ventricular territories with region-of-interest pointing towards E representative histological (Hematoxylin Eosin Stain) overview of IC, BZ and RM. Scale bar 2.5 mm. F Histology of BZ/RM at identical region-of-interest with staining for macrophages (CD68, green) and TNF-α (red); Scale bar 50 µm. The blue line is highlighting the border of structurally intact cardiomyocytes as delineated by autofluorescence. Within BZ, there is a clear overlap of TNF-α + spots with CD68 + spots. In RM, blue arrows point towards TNF-α spots within cardiomyocytes as delineated by their autofluorescence. Correlation of whole heart ¹⁹F integral with end diastolic volume index (G) and sphericity volume index (H)