Table 2.
Arithmetic mean (%CV) summary of posaconazole plasma PK parameters on day 10 in Asian participants administered posaconazole IV 300 mg twice daily on day 1 followed by posaconazole IV 300 mg once daily until at least day 10 (all PK-evaluable participants; intensive PK sampling subgroup; n = 27)
| Cavg,ss (ng/mL) | AUC0-24 h (h × ng/mL) | Cmax (ng/mL) | Cmin (ng/mL) | Tmax (h) | CL (mL/h) | |
|---|---|---|---|---|---|---|
| Mean | 2986 | 71,671 | 4612 | 2311 | 1.7 | 4768 |
| %CV | 36.0 | 36.0 | 26.5 | 48.4 | 13.9 | 37.9 |
| Median | 3011.3 | 72,270.9 | 4670.0 | 2150.0 | 1.7 | 4151.1 |
| Range | 1409.2–5530.4 | 33,820.5–132,730.2 | 2500.0–8480.0 | 812.0–4800.0 | 1.0–1.9 | 2260.2–8870.4 |
| Geometric mean | 2801.3 | 67,231.3 | 4465.8 | 2057.1 | 1.6 | 4462.2 |
AUC0-24h area under the curve from time zero to 24 h, Cavg,ss steady state average concentration, CL clearance, Cmax maximum concentration, Cmin minimum concentration, IV intravenous, %CV coefficient of variation, PK pharmacokinetics, Tmax time to maximum concentration