TABLE 2.

Comparison of the pharmacokinetic parameters of Warfarin (n = 3).

Parameter	Control	Antibiotic-3days	Antibiotic-7days
AUC(0-t)/mg/L*h	20.301 ± 0.494	23.877 ± 0.58	43.821 ± 0.57**
AUC(0-∞)/mg/L*h	21.217 ± 0.784	27.193 ± 0.717*	56.34 ± 1.472**
MRT (0-t)/h	20.854 ± 0.573	23.865 ± 0.246	26.971 ± 0.181*
t1/2z/h	15.468 ± 1.47	23.383 ± 0.85*	32.454 ± 1.751**
Tmax/h	4	4	1*
CLz/F/L/h/kg	0.009 ± 0.001	0.007 ± 0.001	0.004 ± 0.001*
Vz/F/L/kg	0.21 ± 0.013	0.248 ± 0.009	0.166 ± 0.006*
Cmax/mg/L	0.607 ± 0.006	0.647 ± 0.012	1.06 ± 0.006**

Note: *means p < 0.05; **means p < 0.01.