TABLE 3.

Comparison of the pharmacokinetic parameters of Dabigatran (n = 3).

Parameter	Control	Antibiotic-3days	Antibiotic-7days
AUC(0-t)/mg/L*h	2.350 ± 0.619	3.609 ± 2.139*	2.101 ± 0.347
AUC(0-∞)/mg/L*h	2.351 ± 0.619	3.612 ± 2.143*	2.102 ± 0.347
MRT (0-t)/h	8.505 ± 2.325	7.633 ± 0.501	11.472 ± 3.193
t1/2z/h	6.008 ± 0.256	5.816 ± 1.216	5.688 ± 0.631
Tmax/h	1.25 ± 0.433	2 ± 1.000	2
CLz/F/L/h/kg	8.994 ± 2.776	6.723 ± 3.009	9.678 ± 1.459
Vz/F/L/kg	78.335 ± 26.335	54.512 ± 23.175*	80.218 ± 19.538
Cmax/mg/L	0.392 ± 0.042	0.904 ± 0.508**	0.218 ± 0.097

Note: *means p < 0.05; **means p < 0.01.