Table 1.
Antiviral interferon-induced genes in this study.
| Gene symbol | PEDV infection | TGEV infection | PEDV+TGEV infection | Gene description | Ref DOI | |||
|---|---|---|---|---|---|---|---|---|
| log2 fold change | q value | log2 fold change | q value | log2 fold change | q value | |||
| APOBEC3B | 0.853622611 | 3.47E-09 | 0.716693607 | 0.002364504 | 0.953401477 | 1.82169E-06 | Apolipoprotein B mRNA editing enzyme catalytic subunit 3B | 10.1038/nature00939 |
| DDX24 | 0.227246637 | 0.039698472 | 0.295532008 | 0.04570764 | 0.304417963 | 0.020049853 | DEAD-box helicase 24 | 10.1016/j.virol.2008.01.025 |
| DDX60 | 1.110014124 | 0.048911194 | 0.998530685 | 0.032603554 | 0.955513667 | 0.013291317 | DExD/H-box helicase 60 | 10.1038/nature09907 |
| IFI6 | 1.479421789 | 0.000611615 | 1.864487534 | 5.95363E-07 | 1.377998512 | 3.09053E-05 | Interferon alpha inducible protein 6 | 10.1038/s41564-018-0244-1 |
| IFIT2 | 2.292753267 | 0.005583963 | 2.170059221 | 0.010245215 | 2.269357635 | 0.007031308 | Interferon-induced protein with tetratricopeptide repeats 2 | 10.1371/journal.pbio.2004086 |
| IFIT3 | 1.897685589 | 0.008779897 | 1.658142819 | 0.001373656 | 1.911377054 | 0.011643211 | Interferon-induced protein with tetratricopeptide repeats 3 | 10.1371/journal.pbio.2004086 |
| IFITM1 | 2.188304133 | 7.74E-08 | 2.519998152 | 1.35833E-10 | 1.987652389 | 1.70188E-10 | Interferon-induced transmembrane protein 1 | 10.1016/j.cell.2009.12.017 |
| IFITM3 | 1.132823871 | 4.43E-10 | 1.434383357 | 3.99482E-06 | 1.113465091 | 9.84344E-07 | Interferon-induced transmembrane protein 3 | 10.3389/fimmu.2018.00228 |
| ISG12(A) | 1.822958691 | 0.00000265 | 2.186524528 | 7.21423E-08 | 1.614782083 | 3.25923E-07 | Putative ISG12(a) protein | 10.1128/JVI.00352-16 |
| ISG15 | 2.302352998 | 0.00000341 | 2.663277381 | 6.77695E-09 | 2.05115159 | 3.77527E-08 | ISG15 ubiquitin-like modifier | 10.1371/journal.pbio.2004086 |
| ISG20 | 1.742182074 | 0.000108971 | 1.948342895 | 1.72743E-06 | 1.502146139 | 3.99749E-06 | Interferon stimulated exonuclease gene 20 | 10.1371/journal.pbio.2004086 |
| MOV10 | 1.493423741 | 2.6E-18 | 1.639326559 | 1.46511E-08 | 1.205502595 | 1.4368E-07 | Mov10 RISC complex RNA helicase | 10.1371/journal.pbio.2004086 |
| OAS1 | 1.332989798 | 2.97E-09 | 1.421244578 | 1.39396E-05 | 1.215590342 | 1.36733E-05 | 2′-5′-Oligoadenylate synthetase 1 | 10.1371/journal.pbio.2004086 |
| OAS2 | 1.206408548 | 4.93E-08 | 1.117235101 | 0.000354723 | 1.127790413 | 5.62295E-05 | 2′-5′-Oligoadenylate synthetase 2 | 10.3390/v12040418 |
| OASL | 2.319409818 | 0.000176627 | 2.883551358 | 1.62918E-09 | 2.127805209 | 0.001844082 | 2′-5′-pligoadenylate synthetase like | 10.1016/j.immuni.2018.12.013 |
| PARP12 | 1.21350878 | 0.00365218 | 1.225430781 | 0.000345214 | 1.012772207 | 0.001336873 | Poly(ADP-ribose) polymerase family member 12 | 10.1371/journal.pbio.2004086 |
| PLSCR1 | 0.843484336 | 0.000034 | 0.81086527 | 0.004374285 | 0.825097418 | 0.001428997 | Phospholipid scramblase 1 | 10.1128/JVI.78.17.8983-8993.2004. |
| PML | 1.110555091 | 4.43E-08 | 1.189068424 | 7.19109E-05 | 1.117956227 | 9.76855E-06 | Promyelocytic leukemia | 10.1371/journal.pbio.2004086 |
| RSAD2 | 1.739470018 | 0.025127966 | 1.263835725 | 0.026307427 | 1.743586308 | 0.032480782 | Radical S-adenosyl methionine domain-containing 2 | 10.1016/j.virusres.2019.01.014 |
| SAMHD1 | 1.57993947 | 0.0000295 | 1.561018618 | 1.70923E-05 | 1.419359396 | 1.79687E-05 | SAM and HD domain-containing deoxynucleoside triphosphate triphosphohydrolase 1 | 10.1016/j.tim.2015.08.002 |
| SAT1 | 1.234166325 | 0.000000407 | 1.816910382 | 4.24858E-08 | 1.202642104 | 0.000799724 | Spermidine/spermine N1-acetyltransferase 1 | 10.1371/journal.pbio.2004086 |
| SHISA5 | 1.013779953 | 3.45E-10 | 1.139773973 | 9.82032E-06 | 0.854640948 | 2.51898E-05 | Shisa family member 5 | 10.1038/ncomms10631 |
| TRIM11 | 0.79732917 | 0.000000202 | 0.859346252 | 0.000532122 | 0.642531515 | 0.000439271 | Tripartite motif containing 11 | 10.1371/journal.ppat.0040016 |
| TRIM14 | 0.929915084 | 0.00000209 | 0.638263983 | 0.023485833 | 1.033985153 | 5.19874E-05 | Tripartite motif containing 14 | 10.3389/fmicb.2019.00344 |
| TRIM56 | 1.109190465 | 7.78E-08 | 0.868601165 | 0.017945664 | 0.908904097 | 0.000233247 | Tripartite motif containing 56 | 10.1371/journal.pntd.0007537 |
| ZC3HAV1 | 1.260902829 | 3.74E-09 | 0.78703522 | 0.021422393 | 1.01385866 | 9.58972E-05 | Zinc finger CCCH-type antiviral protein 1 | 10.1371/journal.pbio.2004086 |
| ZNFX1 | 1.244001392 | 0.016690307 | 0.937197617 | 0.021673342 | 1.272066064 | 0.000428093 | Zinc finger NFX1-type containing 1 | 10.1038/s41556-019-0416-0 |