Table 2.

Diagnosis in the biopsy versus resection specimen, stratified for the biopsy size < and ≥ 4 mm² and stratified for Ki-67 < and ≥ 3 (B) and 5% (C). Note that none of the AC could be diagnosed in biopsies < 4 mm² and when AC was diagnosed on the biopsy, it was always concordant with the resection specimen (underscored A). Ki-67 was not of additional value for discrimination between TC and AC in the biopsy (underscored B and C). Biopsy size combined with a Ki-67 < and ≥ 5% did not increase diagnostic accuracy (D). *Ki-67 missing (n = 1)

	Diagnosis resection
	TC	AC	Total
A
Diagnosis TC biopsy < 4mm2	6	15	21
Diagnosis TC biopsy ≥ 4mm2	20	14	34
Diagnosis AC biopsy < 4mm2	0	0	0
Diagnosis AC biopsy ≥ 4mm2	0	9	9
	26	38	64
B
Diagnosis TC biopsy Ki-67 < 3%	17	20	37
Diagnosis TC biopsy Ki-67 ≥ 3%	9	8	17
Diagnosis AC biopsy Ki-67 < 3%	0	4	5
Diagnosis AC biopsy Ki-67 ≥ 3%	0	5	5
	26	37	63*
C
Diagnosis TC biopsy Ki-67 < 5%	18	23	42
Diagnosis TC biopsy Ki-67 ≥ 5%	8	5	12
Diagnosis AC biopsy Ki-67 < 5%	0	5	5
Diagnosis AC biopsy Ki-67 ≥ 5%	0	4	4
	26	37	63*
D
Biopsy < 4mm2 and Ki-67 < 5%	5	13	19
Biopsy < 4mm2 and Ki-67 ≥ 5%	1	1	2
Biopsy ≥ 4mm2 and Ki-67 < 5%	13	15	28
Biopsy ≥ 4mm2 and Ki-67 ≥ 5%	7	8	15
	26	37	63*