Table 3.
Univariate and multivariate Cox regression survival analysis. Parameters BCL3 (either cytosolic or nuclear), estrogen receptor, HER2/Neu, and lymph node metastasis (N) were included (forward conditional) into the model. For multivariate Cox regression, the maximal p to be included into the model was set to 0.2. HR, hazard ratio. *Analysis restricted to ER-positive and tamoxifen-treated cases
| Univariate cox regression | |||
|---|---|---|---|
| Parameter | HR | 95% CI | p |
| BCL3 cyt. * |
1.853 5.095 |
1.002–3.428 2.281–11.381 |
0.049 < 0.001 |
| BCL3 nucl. * |
2.483 5.379 |
1.350–4.566 2.411–12.003 |
0.003 < 0.001 |
| ER | 0.654 | 0.396–1.081 | 0.098 |
| HER2/NEU | 1.700 | 1.034–2.795 | 0.036 |
| N | 1.841 | 1.174–2.887 | 0.008 |
| Multivariate cox regression | |||
| BCL3 cyt* |
1.790 5.669 |
0.945–3.390 2.520–12.754 |
0.074 < 0.001 |
| HER2/Neu* |
1,716 2.867 |
0.902–3.268 1.272–6.462 |
0.100 0.011 |
| N* |
1.918 1.977 |
1.044–3.522 0.886–4.409 |
0.036 0.096 |
| Multivariate cox regression | |||
| BCL3 nuc. * |
2.857 6,740 |
1.536–5.312 2.764–16.436 |
0.001 < 0.001 |
| HER2/Neu* | 2.014 | 0.889–4.562 |
> 0.2 0.093 |
| N* |
1.988 2.849 |
1.083–3.648 1.210–6.707 |
0.026 0.017 |