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. 2022 Apr 7;12:145. doi: 10.1038/s41398-022-01884-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A, B. Bar plot illustrating the explained variance for the association of schizophrenia-PRS with binary outcome at several p_t, adjusted for sex, age, and 10 PCs. p_t are displayed on the X-axis, where the number of included SNPs increases with more lenient p_t. Δ Explained variance represents the Nagelkerke R² (shown as %). The red dots represent the significance of the association results (-Log 10 p value). The dashed line represents a nominal significance-level of p < 0.05 (A). Individual risk prediction: higher schizophrenia-PRS was associated with higher positive predictive value for low symptom severity. Whiskers represent confidence intervals (±1.96 × standard error) around the central positive predictive value estimate (B).