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. 2022 Apr 7;13:1887. doi: 10.1038/s41467-022-28795-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The distribution of the scalar projection for individuals from ADNI2/GO in the Clinically Stable (n = 100), Clinically Declining (n = 156) and Alzheimer’s clinical syndrome (n = 181) groups (APOE 4 positive: n = 116, APOE 4 negative n = 140), the red line is the median of the group, the solid black box represents the 25th to 75th percentile and the black horizontal lines represent the range of the data, red crosses are outliers from the distribution, non-overlapping notches indicate significantly different medians (p < 0.05). Blue dots indicate individuals from ADNI3/BACS who are cognitively normal (CN) at baseline. Red dots indicate individuals from ADNI3 who have Mild Cognitive Impairment (MCI) at baseline. The dashed vertical black line represents the probabilistic boundary used to classify Clinically Declining vs. Clinically Stable, all individuals to the right of the line are classified as Clinically Declining. Source data are provided as a Source Data file.