Fig. 7. Prediction accuracy of future tau accumulation in the BACS Clinically Declining sample.

Comparing predicted tau accumulation to observed tau accumulation for individuals classified as Clinically Declining in the BACS cohort. a Fit of the predicted future rate of tau accumulation to the observed tau accumulation within the fusiform gyrus (R² = 41%). The central black line indicates the regression line for the fit of predicted vs. observed future rate of tau accumulation; the dashed lines indicate the 95% confidence intervals for this regression line. One outlier based on the scalar projection is not shown. b Percentage of shared variance of the predicted regional future tau accumulation and the observed future tau accumulation for Clinically Declining individuals within each of the selected ROIs (Fig. 6a). Source data are provided as a Source Data file.