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. 2022 Apr 7;6:24. doi: 10.1038/s41698-022-00263-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Novel tracer development of a putative CD8 tracer, based on small-antibody alternatives, which could then be integrated with existing tracers to image activated CD-8 cells, such as ¹⁸F- arabino-furanosylguanine (ARA-G). Combination studies with T-cell tracers and tracers for PD-L1/PD-1 such as adnectin ¹⁸F-18F-BMS-986192 could help determine the causes of immunotherapy resistance in patients on ICI, as well as being used to investigate the mechanisms of therapeutic strategies such as induction of abscopal effects after radiotherapy.