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. 2022 Apr 7;13:1891. doi: 10.1038/s41467-022-29413-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Body weight change of C57BL/6 mouse treated with 20 mg/kg NK01-63 or water vehicle via intraperitoneal (IP) or oral (PO) dose for 14 consecutive days on an in vivo toxicity study. Data are plotted as the mean ± s.d., n = 10 biological replicates. Two-tailed t test were performed on weight of 14 days post initial treatment. P^ns of IP = 0.07, P^ns of PO = 0.68. b, c Molar concentration of NK01-63 in plasma or lung of C57BL/6 mouse 0 h, 2 h, 4 h, 8 h, or 24 h after treatment with 20 mg/kg NK01-63 via intraperitoneal (IP) or oral (PO) dose. Data are plotted as the mean ± s.d., n = 8 biological replicates. EC₉₀ value of NK01-63 is from Caco-2 cell-based SARS-CoV-2 antiviral assay. Source data are provided as a Source Data file.