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SARS-CoV-2 inhibition data for GC376 analogs.
| Entry | SARS-CoV-2 3CLpro IC50 (nM) | SARS-CoV-2 3CLpro kinact/KI (min−1 µM−1) | SARS-CoV-2 Vero E6 EC50 (µM) | SARS-CoV-2 Huh-7ACE2 EC50 (nM) | SARS-CoV-2 Caco-2 EC90 (nM) |
|---|---|---|---|---|---|
| GC376 | 35 | 1.3 | 9 | 51 | |
| EB46 | 23 | 3.3 | 2 | 14 | 53 |
| EB48 | 200 | 2.1 | 16 | ||
| EB54 | 29 | 5.3 | 2 | 5 | 190 |
| EB55 | 72 | 1.3 | 3 | 11 | |
| EB56 | 50 | 1.1 | 4 | 28 | |
| SL-4-241 | 75 | 1.4 | 17 | ||
| NK01-14 | 22 | 4.3 | 26 | ||
| NK01-48 | 92 | 0.3 | 15 | ||
| NK01-57 | 13 | NA | 92 | ||
| NK01-63 | 16 | 4.4 | 6 | 81 | |
| NK01-69 | 24 | 4.2 | 35 |
