. 2000 Jun;44(6):1470–1478. doi: 10.1128/aac.44.6.1470-1478.2000

TABLE 2.

Amino acid identities of chromosome- and plasmid-encoded AmpCs^a

Cephalosporinase	% Amino acid identity
	Chromosome-encoded cephalosporinases											Plasmid-encoded cephalosporinases
	S. mar	P. stu	L. lac	P. imm	E. clo	C. fre	E. col	Y. ent	M. mor	A. sob	P. aer	ACC-1	CMY-1	CMY-2	DHA-1	FOX-1	MOX-1	MIR-1
H. alv ACC-2	49	47	41	40	35	37	36	38	35	40	42	94	40	37	35	42	36	36
S. mar		51	43	38	40	38	39	37	39	42	43	50	42	39	39	44	38	36
P. stu			38	35	33	34	32	35	35	36	36	48	36	32	35	38	33	32
L. lac				37	37	36	35	33	33	40	41	42	44	35	33	43	39	35
P. imm					36	36	35	38	40	40	38	40	42	36	40	39	34	35
E. clo						73	69	53	54	42	42	35	41	75	54	42	37	86
C. fre							76	55	55	41	40	37	40	95	55	40	35	74
E. col								57	57	41	41	36	40	77	57	41	35	71
Y. ent									51	40	42	37	39	55	51	41	34	54
M. mor										42	45	35	41	55	100	44	37	55
A. sob											53	41	73	42	42	73	65	41
P. aer												40	53	40	45	53	46	43
ACC-1													42	37	35	42	37	35
CMY-1														40	41	72	88	39
CMY-2															55	40	34	76
DHA-1																44	37	55
FOX-1																	63	41
MOX-1																		34

Percent identity between amino acid sequences of chromosome-encoded AmpCs and representative plasmid-encoded cephalosporinases from gram-negative rods. The abbreviations and origins for the chromosome-borne cephalosporinases are as follows: H. alvei, H. alv AAC-2 (this study); Serratia marcescens, S. mar (36); Providentia stuartii, P. stu (Koeck et al., GenBank accession no. Y17315); Lysobacter lactamgenus, L. lac (Kimura et al., GenBank no. S54103); Psychrobacter immobilis, P. imm (12); Enterobacter cloacae, E. clo (14); Citrobacter freundii, C. fre (26); Escherichia coli, E. col (24); Yersinia enterocolitica, Y. ent (43); Morganella morganii, M. mor (40); Aeromonas sobria, A. sob (41); Pseudomonas aeruginosa, P. aer (29). The plasmid-encoded cephalosporinases are ACC-1 from K. pneumoniae KUS (6), CMY-1 from K. pneumoniae (8), CMY-2 from K. pneumoniae (7), DHA-1 from Salmonella enteritidis (3), FOX-1 from K. pneumoniae (15), MOX-1 from K. pneumoniae (20), and MIR-1 from K. pneumoniae (23).