Table 3.

Adjusted mean score differences with 95 % confidence intervals in QLQ-C30 and QLQ-FA12 fatigue scores between patients with and without predefined medical complications after esophagectomy at different time points^a

	QLQ-C30 fatigue			QLQ-FA12 fatigue
	1 Year	1.5 Years	2 Years	1 Year	1.5 Years	2 Years
Complications
No	Reference	Reference	Reference	Reference	Reference	Reference
Yes	1.0 (−4.9 to 6.8)	5.6 (−0.7 to 12.0)	3.1 (−3.6 to 9.8)	1.4 (−3.2 to 6.0)	5.3 (0.4–10.2)	2.2 (−2.9 to 7.4)
Clavien-Dindo classification
0–1	Reference	Reference	Reference	Reference	Reference	Reference
2–3a	− 1.4 (− 7.9 to 5.1)	4.7 (− 2.3 to 11.6)	1.6 (−5.8 to 9.0)	0.6 (−4.5 to 5.7)	5.4 (−0.0 to 10.8)	0.6 (−5.1 to 6.3)
3b–4	5.3 (−2.0 to 12.5)	8.0 (0.1–15.8)	5.6 (−2.7 to 13.8)	2.0 (−3.7 to 7.7)	5.4 (−0.7 to 11.5)	5.0 (−1.4 to 11.4)
Complication group
Surgical complication
No	Reference	Reference	Reference	Reference	Reference	Reference
Yes	−0.7 (−6.8 to 5.3)	−3.1 (−9.7 to 3.5)	−3.8 (−10.9 to 3.2)	−2.5 (−7.3 to 2.3)	−2.8 (−7.9 to 2.3)	−2.6 (−8.1 to 2.8)
Medical complication
No	Reference	Reference	Reference	Reference	Reference	Reference
Yes	0.4 (−5.3 to 6.1)	5.4 (−0.7 to 11.5)	3.3 (−3.2 to 9.8)	0.7 (−3.8 to 5.1)	5.0 (0.2–9.7)	2.8 (−2.2 to 7.8)
Pulmonary complication
No	Reference	Reference	Reference	Reference	Reference	Reference
Yes	0.3 (−5.9 to 6.5)	4.2 (−2.5 to 10.8)	3.0 (−4.0 to 10.0)	0.3 (−4.6 to 5.2)	5.8 (0.7–11.0)	1.9 (−3.5 to 7.3)
Cardiac complication
No	Reference	Reference	Reference	Reference	Reference	Reference
Yes	−1.6 (−9.3 to 6.1)	4.6 (−3.6 to 12.8)	−1.3 (−10.1 to 7.5)	−1.1 (−7.2 to 5.0)	0.6 (−5.8 to 7.0)	0.6 (−6.2 to 7.4)

^aValues in bold are both clinically relevant and statistically significant