Table 1.
Clinical annotations of all patients
| Patient | Primary tumor | Metastatic site | CTC collection | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Histology | ER | PR | HER2 | Type | ER | PR | HER2 | Overall treatment history | Therapy at time of metastasis diagnosis | Therapy at visit 1 | Therapy at visit 2 | |
| 1 | N/A | Y | N | N | Pleural effusion | Y | N | N | Everolimus/exemestane, paclitaxel/capecitabine/zoledronic acid, doxorubicin, gemcitabine | Doxorubicin | Doxorubicin | Gemcitabine |
| 2 | N/A | N/A | N/A | N/A | LN | Y | Y | N | ALND + XRT, tamoxifen, anastrozole/ lanreotide | None | None | |
| 3 | IDC | N | N | N | Brain | N | N | N | Segmental mastectomy/ SLN+ IORT, docetaxel/ cyclophosphamide, XRT, capecitabine/ denosumab | Capecitabine | Capecitabine | |
| 4 | PLC | Y | Y | N | Ascites | N/A | N/A | N/A | Anastrozole/palbociclib, paclitaxel, doxorubicin | Doxorubicin | Doxorubicin | |
| 5 | N/A | Y | Y | N | Liver | Y | Y | N | Chemotherapy (unknown)/ XRT, tamoxifen, paclitaxel/cisplatin, anastrozole, palbociclib/letrozole | Letrozole + palbociclib | Letrozole + palbociclib | |
| 6 | N/A | Y | N | N | Brain | Y | N | N | Chemotherapy (unknown) + right mastectomy, anastrozole | Anastrozole | Anastrozole | |
| 7 | IDC | Y | Y | N | Breast | Y | Y | N | Lumpectomy | None | None | |
| 8 | N/A | Y | Y | N | Ascites | N/A | N/A | N/A | Lumpectomy/ chemotherapy (unknown)/ radiation, carboplatin/paclitaxel, anastrozole, fulvestrant/ palbociclib, capecitabine, doxorubicin, everolimus/exemestane | Doxorubicin | Doxorubicin + gemcitabine | Gemcitabine + exemestane + everolimus |
| 9 | IDC | Y | Y | N | Pleural effusion | Y | N | N | Dose dense adriamycin/ cyclophosphamide, MRM, paclitaxel, tamoxifen/ XRT, anastrozole, leuprolide/ zoledronic acid, fulvestrant/ leuprolide depot, capecitabine, everolimus/ exemestane, paclitaxel, doxorubicin | Paclitaxel > doxorubicin | Paclitaxel > doxorubicin | |
| 10 | IDC | Y | Y | N | Breast | Y | Y | N | Doxorubicin/ cyclophosphamide/ paclitaxel, left segmental mastectomy with lymphadenectomy, tamoxifen/ leuprolide/ zoledronic acid + XRT, exemestane/ leuprolide/ zoledronic acid, fulvestrant/ palbociclib, capecitabine + XRT, | Capecitabine | Capecitabine+ XRT | Paclitaxel |
| 11 | IDC | N | N | N | CSF | N | N | N | Adriamycin/cyclophosphamide, paclitaxel, right MRM + ALND + XRT, right craniotomy w/ removal right occipital mass + cytarabine, carboplatin/ capecitabine | Carboplatin + capecitabine | Carboplatin + capecitabine | |
| 12 | ILC | N | N | N | Bone | N/A | N/A | N/A | Segmental mastectomy, brachytherapy, docetaxel/ cyclophosphamide, doxorubicin/cyclophosphamide/ paclitaxel + XRT, anastrozole, letrozole, capecitabine | Capecitabine, letrozole | Capecitabine + letrozole | |
| 13 | IDC+IBC | N | N | N | Brain | N | N | Y | Simple mastectomy, carboplatin/taxotere+ radical mastectomy, gemcitabine/trastuzumab, surgical excision by suboccipital craniotomy + gamma knife | None | None | |
| 14 | IDC | Y | Y | N | Breast | Y | N | N | Adriamycin/ cyclophosphamide, paclitaxel, tamoxifen, mastectomy + XRT, leuprolide/ anastrozole | Leuprolide + anastrozole | Leuprolide + anastrozole | |
| 15 | IDC | Y | Y | N | Pleural effusion | Y | N | N | Adriamycin/ cyclophosphamide /docetaxel, BMX + bilateral ALND, capecitabine + XRT, tamoxifen, leuprolide/ zoledronic acid, capecitabine, gemcitabine/ carboplatin | Capecitabine | Capecitabine | Gemcitabine + carboplatin |
| 16 | IDC | N/A | N/A | N/A | Pleural effusion | N | N | N | Adriamycin/ cyclophosphamide, paclitaxel, tamoxifen, mastectomy | None | None | |
| 17 | N/A | Y | N | N | CSF | Y | N | N | Mastectomy/ adjuvant chemotherapy/ XRT + adjuvant hormonal therapy, anastrozole, fulvestrant, paclitaxel/ capecitabine, carboplatin, vinorelbine | Gemcitabine | Vinorelbine | |
| 18 | IDC+ILC | Y | N | N | Skin | Y | N | N | Letrozole + XRT | XRT + letrozole | Letrozole | |
| 19 | IDC | Y | Y | Y | Pleural effusion | N/A | N/A | N/A | Docetaxel/ trastuzumab/ pertuzumab, trastuzumab/ pertuzumab/ letrozole | Docetaxel + Trastuzumab + pertuzumab | Docetaxel + Trastuzumab + pertuzumab | |
ALND: axillary node dissection; CSF: cerebrospinal fluid; IBC: inflammatory breast cancer; IDC: invasive ductal carcinoma; ILC: invasive lobular carcinoma; IORT: intraoperative radiation therapy; PLC: pleomorphic lobular carcinoma; LN: lymph node; MRM: modified radical mastectomy; SLN: sentinel lymph nodes; WBRT: whole brain radiation therapy; XRT: radiotherapy; BMX: bilateral mastectomy; N/A: information not available.