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. 2022 Apr 7;12:4099. doi: 10.1038/s41598-022-08085-4

Table 2.

Associations between lifetime use of various substances and opioid use disorder (OUD).

Lifetime use Frequency (unweighted N) aOR (95% CI)1
Psilocybin 22,276 0.70*** (0.60, 0.83)
Peyote 3766 0.84 (0.63, 1.12)
Mescaline 4595 1.13 (0.86, 1.49)
LSD 22,552 1.15 (0.94, 1.42)
MDMA/ecstasy 21,195 1.66*** (1.35, 2.03)
PCP 3935 1.63** (1.25, 2.12)
Cocaine 32,783 3.54*** (2.89, 4.34)
Inhalants 21,856 1.44*** (1.21, 1.73)
Tranquilizers 48,572 3.40*** (2.79, 4.14)
Stimulants 32,033 1.44*** (1.24, 1.68)
Sedatives 27,218 1.93*** (1.61, 2.30)
Marijuana 110,175 2.39*** (1.71, 3.35)

1*p < 0.05; **p < 0.01; ***p < 0.001; aOR adjusted odds ratio, CI confidence interval. Significant values that indicate lowered odds of OUD are in bold.