Table 3.
Associations between psilocybin and the 11 DSM-IV criteria for opioid dependence and abuse.
| Opioid dependence and abuse criteria | Frequency (unweighted N) | aOR (95% CI) (psilocybin as independent variable)1 |
|---|---|---|
| 1. Significant time spent getting/using | 2249 | 0.83* (0.70, 0.98) |
| 2. Use more than intended | 1030 | 0.71* (0.54, 0.93) |
| 3. Decreased effects/need more for same effect | 2901 | 0.82* (0.70, 0.96) |
| 4. Unable to cut back | 914 | 0.80† (0.62, 1.04) |
| 5. Emotional/physical health problems | 1383 | 0.73** (0.60, 0.90) |
| 6. Fewer important activities | 1320 | 0.71** (0.58, 0.87) |
| 7. 3 + Withdrawal symptoms | 1724 | 0.86 (0.71, 1.05) |
| 8. Significant work/home/school problems | 1063 | 0.66** (0.50, 0.86) |
| 9. Use in physically hazardous situations | 910 | 0.66** (0.49, 0.88) |
| 10. Recurrent legal trouble | 454 | 0.72 (0.45, 1.15) |
| 11. Social/interpersonal issues | 906 | 0.75† (0.56, 1.01) |
1†p < 0.10; *p < 0.05; **p < 0.01; ***p < 0.001; aOR adjusted odds ratio, CI confidence interval. Significant values that indicate lowered odds of OUD criteria are in bold.