TABLE 2.
ED50 of Hsn-5, Hsn-5 variants R12I/K17N and R12I/H21L, and MUC7 D1 against various fungal strains
| Fungus | ED50 [μM] (95% confidence limits)a
|
|||
|---|---|---|---|---|
| Hsn-5 | R12I/K17N | R12I/H21L | MUC7 D1 | |
| Candida albicans | 6.68 (6.05–7.37) | 6.83 (6.11–7.64) | 5.12 (4.5–6.14) | 6.02 (4.85–7.43) |
| Candida albicans (azole resistant) | 6.4 (5.59–7.32) | 24.55 (19.7–30.92) | 7.67 (5.49–10.97) | 5.24 (4.75–5.80) |
| Cryptococcus neoformans | 3.71 (1.92–5.60) | 17.2 (14.33–20.69) | 5.16 (4.25–6.32) | 3.27 (2.77–3.89) |
| Cryptococcus neoformans (amphotericin B resistant) | 3.72 (2.9–4.87) | 6.76 (5.84–7.83) | 4.56 (4.15–5.01) | 3.67 (2.8–4.52) |
| Candida glabrata | 38.70 (30.81–50.70) | >100 | 31.6 (21.38–49.85) | 11.46 (8.34–16.06) |
| Candida glabrata (azole resistant) | 85.35 (78.44–94.05) | >100 | 17.2 (14.18–20.9) | 5.5 (4.99–6.08) |
| Candida krusei | 6.47 (5.79–7.55) | 56.4 (46.87–70.10) | 9.5 (7.52–12) | 3.82 (3.49–4.19) |
| Saccharomyces cerevisiae | 74.03 (58.06–101.35) | >100 | 12.04 (9.36–15.41) | 9.73 (5.66–5.83) |
a
The results are based on three separate experiments, each run in triplicate.