Table 2.
Cox regression analysis of left ventricular diastolic dysfunction (LVDD; E/e′ > 14) for clinical outcomes.
| Events, n (%) | Model 1 | Model 2 | Model 3 | Model 4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| HR (95%CIs) | P-value | HR (95%CIs) | P-value | HR (95%CIs) | P-value | HR (95%CIs) | P-value | ||
| Composite CV events | 171 (8.0) | 3.076 (2.127,4.449) |
<0.001 | 2.250 (1.537, 3.219) |
<0.001 | 2.156 (1.461, 3.182) |
<0.001 | 2.194 (1.486, 3.240) |
<0.001 |
| All-cause mortality | 132 (6.2) | 2.846 (1.852, 4.371) |
<0.001 | 2.207 (1.475, 3.301) |
<0.001 | 1.867 (1.198, 2.910) |
0.006 | 1.830 (1.168, 2.869) |
0.008 |
Model 1, unadjusted model; Model 2, model 1 + adjusted for age, sex, Charlson comorbidity index, smoking history, medication (ACEi/ARBs, diuretics, number of antihypertensive drugs, statins), BMI, SBP, and DBP; Model 3, model 2 + adjusted for hemoglobin, albumin, fasting serum glucose, HDL-C, TG, 25(OH) vitamin D, hs-CRP, GFR, and spot urine ACR; Model 4, model 3 + adjusted for EF at the baseline. CI, confidence interval; HR, hazard ratio.